Blar i Brage NIH på forfatter "Viggars, Mark"
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Knockdown of the E3 Ubiquitin ligase UBR5 and its role in skeletal muscle anabolism
Hughes, David C.; Turner, Daniel C.; Baehr, Leslie M.; Seaborne, Robert A.; Viggars, Mark; Jarvis, Jonathan C.; Gorski, Piotr Patryk; Stewart, Claire E.; Owens, Daniel J.; Bodine, Sue C.; Sharples, Adam (Peer reviewed; Journal article, 2020)UBR5 is an E3-ubiquitin-ligase positively associated with anabolism, hypertrophy and recovery from atrophy in skeletal muscle. The precise mechanisms underpinning UBR5's role in the regulation of skeletal muscle mass remains ... -
Mechanical loading of bioengineered skeletal muscle in vitro recapitulates gene expression signatures of resistance exercise in vivo
Turner, Daniel C.; Gorski, Piotr Patryk; Seaborne, Robert A.; Viggars, Mark; Murphy, Mark; Jarvis, Jonathan C.; Martin, Neil R. W.; Stewart, Claire E.; Sharples, Adam P. (Peer reviewed; Journal article, 2021)Understanding the role of mechanical loading and exercise in skeletal muscle (SkM) is paramount for delineating the molecular mechanisms that govern changes in muscle mass. However, it is unknown whether loading of ...